When people first learn about redox signalling molecules, a natural question follows: how many of these molecules does the body actually produce? The answer reveals something remarkable about the scale at which your cells operate and the sheer volume of molecular communication happening inside you right now. A Scale That Defies Intuition Your body contains … Read more
The breakdown of cellular communication does not announce itself. There is no threshold event, no date after which things are measurably worse. The degradation is gradual, operating across years and decades through the incremental accumulation of small failures: signals that arrive slightly delayed, repair responses that are slightly less complete, immune activations that are slightly … Read more
Mitochondria entered biology textbooks as the cell’s powerhouse, a label accurate enough to stick but too narrow to capture what the research has revealed over the past three decades. These double-membraned organelles do produce the ATP that powers cellular life — that part of the textbook is right. What the simplified version misses is that … Read more
In 1956, Denham Harman proposed that ageing was caused by the accumulating damage of free radicals, the reactive molecular fragments produced as byproducts of cellular metabolism. The hypothesis was clean, testable, and it generated enormous research interest. It also produced a corollary that became one of the most commercially successful ideas in health history: if … Read more
Chemistry students encounter redox reactions early and often find them confusing in a specific way. The definitions seem simple — oxidation is the loss of electrons, reduction is the gain — but applying them consistently requires remembering that the two reactions are always paired and always simultaneous. You cannot have one without the other. When … Read more
Your body contains approximately 37 trillion cells. None of them act alone. A muscle cell contracting, an immune cell hunting a pathogen, a liver cell clearing a toxin — each of these is a response to a signal received from somewhere else. Cellular signalling is the communication infrastructure that makes coordinated biology possible, and understanding … Read more
Your cells are talking to each other right now. Not metaphorically. Chemically. Tiny reactive molecules produced inside your mitochondria are carrying signals across and between cells at this moment, telling some cells to divide, others to repair, others to die on schedule before they cause problems. This signalling system is called redox signalling, and researchers … Read more